This book is a comprehensive survey of most of the theoretical and experimental achievements in the field of quantum estimation of states and operations. Albeit still quite young, this field has already been recognized as a necessary tool for research in quantum optics and quantum information, beyond being a fascinating subject in its own right since it touches upon the conceptual foundations of quantum mechanics. The book consists of twelve extensive lectures that are essentially self-contained and modular, allowing combination of various chapters as a basis for advanced courses and seminars on theoretical or experimental aspects. The last two chapters, for instance, form a self-contained exposition