The only generally accepted view is that the dermatosis has multiple etiologies. This monograph is intended to be a follow-up to Simons' book published in 1966, entitled Eczema of the Hands. Investigations into Dyshidrosiform Eruptions. It repre­ sents an attempt to view the clinical and experimental aspects of atopic palmoplantar eczema as a basis for an understanding of the entire entity of dyshidrosis. My special thanks go to Prof. Dr. E. Macher, Miinster, who made it possible for me to complete this work, to Prof. Dr. S. Nolting, Miinster, who aroused my interest in the subject, and to Prof. Dr. P. Frosch, Heidelberg, who generously provided the necessary technical equipment for investiga­ tional use. Clinical examinations are impossible without patients and control per­ sons. I would like to thank all the people who took part in this project.