This monograph aspires to lay the foundations of a new scientific discipline, demoeconomics, representing the synthesis of demography and spatial economics. This synthesis is performed in terms of interaction between population and its economic activity. The monograph appears a unique research work having no analogs in scientific literature. Demoeconomic systems are studied involving the macrosystems approach which combines the generalized entropy maximization principle and the local equilibria principle. Demoeconomic systems operate in an uncertain environment; thus and so, the monograph develops the methodology and technique of probabilistic modeling and forecasting of their evolution. their evolution.