This book constitutes the proceedings of the 14th International Symposium on Search-Based Software Engineering, SSBSE 2022, which was held in Singapore, in November 2022. The 6 regular papers, the NIER and RENE tracks as well as the Challenge Track that were included in this volume were carefully reviewed and selected from 15 submissions. The papers deal with novel ideas and applications of search-based software engineering, focusing on engineering challenges and the application of automated approaches and optimization techniques from AI and machine learning research.