This book constitutes the revised selected papers of the 17th Smoky Mountains Computational Sciences and Engineering Conference, SMC 2020, held in Oak Ridge, TN, USA, in August 2020. The 36 full papers and 1 short paper presented were carefully reviewed and selected from a total of 94 submissions. The papers are organized in topical sections of computational applications: converged HPC and artificial intelligence; system software: data infrastructure and life cycle; experimental/observational applications: use cases that drive requirements for AI and HPC convergence; deploying computation: on the road to a converged ecosystem; scientific data challenges. The conference was held virtually due to the COVID-19 pandemic.