This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Conference on Mobile, Secure and Programmable Networking, held in Mohammedia, Morocco, in April 2019. The 23 papers presented in this volume were carefully reviewed and selected from 48 submissions. They discuss new trends in networking infrastructures, security, services and applications while focusing on virtualization and cloud computing for networks, network programming, software defined networks (SDN) and their security.