The two-volume set LNCS 11442 and 11443 constitutes the refereed proceedings of the 22nd IACR International Conference on the Practice and Theory of Public-Key Cryptography, PKC 2019, held in Beijing, China, in April 2019. The 42 revised papers presented were carefully reviewed and selected from 173 submissions. They are organized in topical sections such as: Cryptographic Protocols; Digital Signatures; Zero-Knowledge; Identity-Based Encryption; Fundamental Primitives; Public Key Encryptions; Functional Encryption; Obfuscation Based Cryptography; Re- Encryption Schemes; Post Quantum Cryptography.¿