The astonishing true story of how Catherine the Great joined forces with a Quaker doctor from Essex to spearhead one of the first global public health campaigns. A TIMES BEST BOOK OF 2022 SO FAR Shortlisted for the Pushkin House Book Prize 2022 'Sparkling history…with a fairytale atmosphere of sleigh rides, royal palaces and heroic risk-taking' The Times A killer virus…an all-powerful Empress…an encounter cloaked in secrecy…the astonishing true story. Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment: a mysterious method called inoculation. But a key problem remained: convincing people to accept the