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Cookie akzeptierenMark J. Van Der Laan / Sandrine Dudoit
Multiple Testing Procedures with Applications to Genomics
- Springer New York
- 2007
- Gebunden
- 628 Seiten
- ISBN 9780387493169
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co- expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
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