"Local Responses to Global Challenges in Southeast Asia - A Transregional Studies Reader" is a collection of multidisciplinary essays, predominantly derived from papers presented at EuroSEAS 2019, the leading academic conference on Southeast Asian Studies, hosted by Humboldt-Universität zu Berlin. It brings together a variety of scholars from Southeast Asia, Europe and North America, allowing for multiple flows and directionalities of knowledge productions and exchanges, be it between the Global South and North as well as within the Global South. The reader presents empirically-oriented, theoretically grounded analyses of local responses to global challenges such as knowledge-productions; notions and practices of building diverse communities; neo-populisms and contentious politics; resources and sustainability; urbanization; labor, livelihoods and mobilities. Each section starts