This book constitutes the refereed proceedings of the First Southwest Data Science Conference, on The Recent Advances in Transdisciplinary Data Science, SDSC 2022, held in Waco, TX, USA, during March 25¿26, 2022. The 14 full papers and 2 short papers included in this book were carefully reviewed and selected from 72 submissions. They were organized in topical sections as follows: Business and social data science; Health and biological data science; Applied data science, artificial intelligence, and data engineering.