The Physiome Project and Virtual Physiological Human (VPH) i- tiative aim to develop advanced computational models that will facilitate the understanding of the integrative function of cells, organs, and organisms, with the ultimate goal of delivering truly personalized medicine. At the same time, progressinreal- timebiomedicalmodeling andsimulationhasenabledmorec- plex, interactive simulations, o?ering the possibility of highly sophisticated task trainers,proceduralandpatientsimulatorsto supportmedicaltrainingandsafer clinical practice. It is in this contextthat ISBMS seeks to act as an international forum for researchers in this increasingly important area to share their latest work, discuss future trends and forge new collaborations.