William Burroughs closed his classic debut novel, Junky , by saying he had determined to search out a drug he called 'Yage' which he believed transmitted telepathic powers, a drug that could be 'the final fix'. In The Yage Letters - a mix of travel writing, satire, psychedelia and epistolary novel - he journeys through South America, writing to his friend Allen Ginsberg about his experiments with the strange drug, using it to travel through time and space, to derange his senses - the perfect drug for the author of the wild decentred books that followed. Years later, Ginsberg writes back as he follows in Burroughs' footsteps, and