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HAROLD A. WITTCOFF has taught industrial organic chemistry at the University of Minnesota, while serving as Vice President of Corporate Research for General Mills Inc. As scientific adviser to Nexant ChemSystems, he has presented 300 courses in industrial chemistry in twenty-eight countries. The late BRYAN G. REUBEN was Professor Emeritus of Chemical Technology at London South Bank University, and was the author or coauthor of 130 publications and a single patent. JEFFREY S. PLOTKIN is Vice President, Chemicals and Technology, at Nexant ChemSystems and is the author or coauthor of twenty-five technical publications and thirty patents.