The book brings together the contributions of the 7th International Conference on Smart Learning Ecosystems and Regional Development (SLERD 2022), which aims at promoting reflection and discussion concerning R&D; work, policies, case studies, and entrepreneur experiences with a special focus on understanding the relevance of smart learning ecosystems (e.g., schools, campus, working places, informal learning contexts, etc.) for regional development and social innovation and how the effectiveness of the relation of citizens and smart ecosystems can be boosted. This forum has a special interest in understanding how technology mediated instruments can foster the citizen's engagement with learning ecosystems and territories, namely by understanding innovative human- centric