This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell¿cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein¿carbohydrate or carbohydrate¿carbohydrate interactions. This book opens by providing the key background on GSL glycan¿receptor interactions and mammalian GSL synthesis. Up-to-date information is then