the foregoing issues, the Executive of the Clarke Institute of Psychiatry of the University of Toronto, with the financial support of the Ministry of Health of the Government of Ontario, organized an inter­ national symposium on May 14-17, 1982, to bring together some of the acknowledged experts in clinical psychopharmacology. This book is, in part, a reflection of that symposium. The editors are aware that a contributed volume, however tightly edited, is not necessarily a textbook. Notwithstanding this, it was thought to be important to assemble expert opinion on current important issues, of immediate concern to the practicing clinician. With this in mind, the chapters have been organized around five themes. Schizophrenia, Affective disorders, and Anxiety, are clearly important since they are the major targets of drug use in psychiatry.