work fits the general purpose of assessing tsunami hazard along the Italian coasts and represents a continuation of a previous study, where the first quantitative description of the 1627 tsunami from a numerical modeling viewpoint was performed (Tinti and Piatanesi, 1996). The earthquake took place on 30 July 1627 about mid-day and was followed by four large aftershocks. It claimed more than 5,000 victims and destroyed completely numerous villages in the northern Gargano area, with the most severe damage located between S. Severo and Lesina. The earthquake excited a tsunami with the most impressive effects in proximity of the Lesina Lake where the most reliable contemporary chronicles report about an initial sea water withdrawal of about 2 miles and a subsequent penetration inland.