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Cookie akzeptieren![Schwechheimer, Susanne Katharina. Riboflavin production with Ashbya gossypii (Band 6) - A 13C high-resolution metabolic network analysis under industrial process conditions. Cuvillier, 2018.](https://eichendorff21.de/cdata/WLLBhddIddh4uFeIbpZi-HQEcw0=/300x0/9783736998810.png)
Susanne Katharina Schwechheimer
Riboflavin production with Ashbya gossypii (Band 6)
- Cuvillier
- 2018
- Taschenbuch
- 174 Seiten
- ISBN 9783736998810
The fungus Ashbya gossypii is an important industrial producer of riboflavin, i.e. vitamin B2. Here, we developed and then used a highly sophisticated set- up of parallel 13C tracer studies with labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR to resolve carbon fluxes and obtain a detailed picture of the underlying metabolism in the overproducing strain A. gossypii B2 during growth and riboflavin production from a complex industrial medium using vegetable oil as carbon source. Glycine was exclusively used as carbon-two ¿ but not carbon- one (C1) ¿ donor of the vitamin¿s pyrimidine ring due to the proven absence of a functional glycine cleavage system.
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