This, the 38th issue of Transactions on Large-Scale Data- and Knowledge- Centered Systems, contains extended and revised versions of six papers selected from the 68 contributions presented at the 27th International Conference on Database and Expert Systems Applications, DEXA 2016, held in Porto, Portugal, in September 2016. Topics covered include query personalization in databases, data anonymization, similarity search, computational methods for entity resolution, array-based computations in big data analysis, and pattern mining.