the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This volume, the 21st issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, focuses on Data Warehousing and Knowledge Discovery from Big Data, and contains extended and revised versions of eight papers selected as the best papers from the 14th International Conference on Data Warehousing and Knowledge Discovery (DaWaK 2012), held in Vienna, Austria, during September 3-6, 2012. These papers cover several advanced Big Data topics, ranging from data cube computation using MapReduce to multiple aggregations over multidimensional databases, from data warehousing systems over complex energy data to OLAP-based prediction models, from extended query engines for continuous stream analytics to popular pattern mining, and from rare pattern mining to enhanced knowledge discovery from large cross-document corpora.