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Cookie akzeptieren![Montecucco, Cesare (Hrsg.). Clostridial Neurotoxins - The Molecular Pathogenesis of Tetanus and Botulism. Springer Berlin Heidelberg, 2013.](https://eichendorff21.de/cdata/CmD7pj4XBUuXjxaOZuujzN2nhDA=/300x0/9783642851759.png)
Clostridial Neurotoxins
- Springer Berlin Heidelberg
- 2013
- Taschenbuch
- 296 Seiten
- ISBN 9783642851759
Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism
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