r-------------{ Environment (Disease) Fig. 1. A schematic presentation of the interplay between the external environment, pathogen and animal, which influences resistance to infectious disease. Disturbance in equilibrium results in infection and disease skin and the mucous membranes of the respiratory tract. These tissues are in contact with the environment, and direct injury to them facilitate entry of pathogenic microorganisms through these important natural barriers. Sunburn and frostbite are examples of such adverse effects. Climatic factors such as heat and cold may also act as physiological stress factors which affect the specific and non-specific responses of the body to infection. 1.1.2 Pathogen Survival Climatic factors may affect