This book constitutes the thoroughly refereed conference proceedings of the 6th International Workshop on Business Intelligence for the Real-Time Enterprise, BIRTE 2012, held in Istanbul, Turkey, in August 2012, in conjunction with VLDB 2012, the International Conference on Very Large Data Bases. The BIRTE workshop series provides a forum to discuss and advance the science and engineering enabling real-time business intelligence and the novel applications that build on these foundational techniques. This volume contains ten research papers, which were carefully reviewed and selected from 13 submissions.