This book discusses how scientific and other types of cognition make use of models, abduction, and explanatory reasoning in order to produce important or creative changes in theories and concepts. It includes revised contributions presented during the international conference on Model-Based Reasoning (MBR¿015), held on June 25-27 in Sestri Levante, Italy. The book is divided into three main parts, the first of which focuses on models, reasoning and representation. It highlights key theoretical concepts from an applied perspective, addressing issues concerning information visualization, experimental methods and design. The second part goes a step further, examining abduction, problem solving and reasoning. The respective contributions analyze different types