This volume constitutes the proceedings of the 10th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2015, held Bilbao, Spain, June 2014. The 60 papers published in this volume were carefully reviewed and selected from 190 submissions. They are organized in topical sections such as data mining and knowledge discovery; video and image analysis; bio-inspired models and evolutionary computation; learning algorithms; hybrid intelligent systems for data mining and applications; classification and cluster analysis, HAIS applications.