This proceedings book contains research papers that are accepted for presentation at the 16th International Conference on Interdisciplinarity in Engineering¿INTER-ENG 2022, which is held on 6¿7 October 2022, in the city of Târgu Mure¿, Romania. The general scope of the conference "Innovative aspects of Industry 4.0" concepts aims at consolidating the digital future of manufacturing in companies" is propsing a new approach related to the development of a new generation of smart factories grounded on the manufacturing and assembly process digitalization. It is related to advance manufacturing technology, lean manufacturing, sustainable manufacturing, additive manufacturing, manufacturing tools and equipment. It is a leading international professional and scientific forum of great interest