This book introduces a variety of well-proven and newly developed nature- inspired optimization algorithms solving a wide range of real-life biomedical and healthcare problems. Few solo and hybrid approaches are demonstrated in a lucid manner for the effective integration and finding solution for a large- scale complex healthcare problem. In the present bigdata-based computing scenario, nature-inspired optimization techniques present adaptive mechanisms that permit the understanding of complex data and altering environments. This book is a voluminous collection for the confront faced by the healthcare institutions and hospitals for practical analysis, storage, and data analysis. It explores the distinct nature-inspired optimization-based approaches that are able to handle