This Open Access book builds on the experiences of one of the largest European projects in the domain of responsible Research and Innovation: NewHoRRIzon. It highlights the potential of and opportunity in responsible R&I; to conduct innovation in a socially responsible way. Employing the methodology of Social Labs, the book analyses responsible R&I; from an experience-based viewpoint and further explores the application of responsible R&I; beyond scholarly and industrial interests. The contributors analyze the current European R&I; landscape, provide reflection and reconceptualization of its core concepts, and project future challenges in relation to responsible R&I.; The book complements the readers' line of work by providing insights