This open access book constitutes the proceedings of the 31st European Symposium on Programming, ESOP 2022, which was held during April 5-7, 2022, in Munich, Germany, as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2022. The 21 regular papers presented in this volume were carefully reviewed and selected from 64 submissions. They deal with fundamental issues in the specification, design, analysis, and implementation of programming languages and systems.