This book constitutes selected revised and extended papers from the 11th International Conference on High-Performance Computing Systems and Technologies in Scientific Research, Automation of Control and Production, HPCST 2021, Barnaul, Russia, in May 2021. The 32 full papers presented in this volume were thoroughly reviewed and selected form 98 submissions. The papers are organized in topical sections on Hardware for High-Performance Computing and Signal Processing; Information Technologies and Computer Simulation of Physical Phenomena; Computing Technologies in Discrete Mathematics and Decision Making; Information and Computing Technologies in Automation and Control Science; and Computing Technologies in Information Security Applications.