This book presents the proceedings of the 2019 International Conference on Intelligent Systems Applications in Multi-modal Information Analytics, held in Shenyang, China on February 19-20, 2019. It provides comprehensive coverage of the latest advances and trends in information technology, science and engineering, addressing a number of broad themes, including data mining, multi-modal informatics, agent-based and multi-agent systems for health and education informatics, which inspire the development of intelligent information technologies. The contributions cover a wide range of topics: AI applications and innovations in health and education informatics; data and knowledge management; multi-modal application management; and web/social media mining for multi-modal informatics. Outlining promising future research directions,