Constantin Bona
Neonatal Immunity
- Humana Press
- 2010
- Taschenbuch
- 404 Seiten
- ISBN 9781617374920
A critical review of the classic, as wells as most recent-and quite seminal- findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines.
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