Early evaluation of potential drug-drug interactions Addressing the potential for adverse interactions among coadministered drugs before marketing a new drug can save time, money, and lives. In this reference, distinguished international experts comprehensively review the issues, relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. Focusing on evaluation during the drug discovery process, Drug- Drug Interactions in Pharmaceutical Development: * Details the major scientific concepts and preclinical experimental approaches * Covers both clinical and nonclinical aspects * Discusses in vitro and in vivo methodologies * Covers genomic approaches * Addresses U.S., European, and Japanese regulations * Includes a chapter on herbal drug interactions Compiling