of the critical data and concepts in this rapidly progressing field of inquiry. Featuring contributions by researchers and clinicians from around the world, this book presents papers covering a broad spectrum of specialized topics in the bacteriology, biochemistry, molecular and cellular interactions, pathophysiology, and pharmacodynamics of sepsis/SIRS. It also presents information on in vivo detection and potential new therapies that target sepsis and its cellular effects. Specific topics covered in Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy include: Enzymes essential to the biosynthesis of Lipid A and their importance in the design of a new generation of antibiotics Recent breakthroughs in the understanding of the role of CD-14 in cellular resistance to infection and its therapeutic implications The role of Interleukin 6 in endotoxin-induced inflammatory response Themolecular mechanisms responsible for endotoxin tolerance Unique chemical and biological features of LPS, and natural and synthetic LPS control mechanisms. Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy is must reading for laboratory and c