Can the creativeness of gene therapists overcome the evolutionary advantage of the immune system? Gene therapy as clinical pharmacology and treatment of disease: Quo vadis?- Introductory overview: How the immune responses to viruses informs the use of viral vectors in gene therapy.- Immune responses to adenoviral vectors in the brain.- Innate and adaptive immune responses to adenoviral vectors administered systemically: cellular and molecular mechanisms.- The immune responses to adenoviral vectors: the clinical experience.- Immune responses to AAV vectors in the CNS.- Immune responses to AAV: experimental approaches and clinical implications.- Immune control of HSV: implications for gene therapy.- Immune responses to HSV vectors: implications for clinical